To date, NPAS3 has been mainly studied in schizophrenia and bipolar disorder72–74 and schizophrenia, especially with negative symptomatology, is another condition in which anhedonia may be a common feature; to our knowledge, this is the first report of an association between NPAS3 and a MDD-related phenotype. The gene discussed is NPAS3; the disease is schizophrenia.