Next, the secretory activity of DCs treated with CRC patients-derived agents was examined and we found that IFNγ (Fig. 12), IL-12p70 (Fig. 14) and sFasL (Fig. 15) were lower in comparison to iDCs, however these DCs were able to significantly increase exocytosis of IL-10 after incubation with lysate/LPS or TCM/LPS (Fig. 13). The gene discussed is IL10; the disease is colorectal carcinoma.