For patients with suspected endometriosis based on presented symptoms and signs, many clinicians begin empirical treatment before making a definitive diagnosis, using medical therapies such as nonsteroidal anti-inflammatory drugs, hormonal contraceptives, progestogens, antiprogestogens, gonadotropin-releasing hormone (GnRH) agonists and antagonists, and aromatase inhibitors [11,12]. This evidence concerns the gene CYP19A1 and endometriosis.