MDM4 and cancer: Among these, 7 genes were analyzed by qRT-PCR in the MCF-7 and BT-20 cells in order to better evaluate the effect of chalcones in some important cancer-related pathways, such as multiple drug resistance (ABCC1, ABCC3 and ABCG2), apoptosis and cell cycle (Bcl-2 and MDM4), growth factor (EGFR) and metastasis (AURKA).