PSEN1 and Spasticity: Furthermore, we identified a lot of variants of other genes associated with different diseases, including LYST [6], SACS, ABCD1, TUBB4A, ALS2, KCNA2, ABHD12, ANO10, CLCN1, CSF1R, GALC, GFAP, KCND3, MECP2, OPA1, PLA2G6, POLR3A, PSEN1, RNASEH1, SLC25A15, SYNE1, TYROBP, VPS13C, and WDR45. These genes were reported as the cause of spasticity as one of the symptoms.