CD8A and hepatocellular carcinoma: A meta-analysis on 23 relevant studies of 3173 hepatocellular carcinoma (HCC) patients showed that high levels of CD8+ and CD3+ TILs had a better prognostic value on the overall survival (OS), yet high levels of FoxP3+ TILs had a worse prognostic value on OS and DFS/Relapse-free survival (RFS), implicating that TILs may serve as a prognostic biomarker in HCC [95].