LAG3 and neoplasm: Those with a higher frequency of somatic mutations and tumor-specific neoantigens were found to have more abundant infiltration of CD8+ T lymphocytes and a higher expression of regulatory molecules (CTLA-4, PD-1, Lymphocyte-activation gene 3[LAG-3] and indolamine 2,3-dioxygenase 1 [IDO1]) [118].