The release of anti-inflammatory cytokines including IL-1, IL-4, IL-5, IL-8, IL-10, TNF, and IFN-γ also allows evasion of the immune system owing to the resultant suppression of immune activity, with the high accumulated level of these cytokines at the liver promoting HCC distant metastasis [128]. This evidence concerns the gene IL1B and hepatocellular carcinoma.