On the contrary, PRDX1 has a tumor promoting role in breast cancer, bladder cancer, oral squamous cell carcinoma, lung cancer, and esophageal squamous cell carcinoma through activation of NF-κB pathway, FOXO1-mediated pathway, and mTOR/p70S6K pathway [40–44]. This evidence concerns the gene NFKB1 and esophageal squamous cell carcinoma.