CD274 and neoplasm: Another interesting observation that we report here is the existence of a strong and positive link between the levels of XDH and the expression levels of multiple genes encoding mediators of inflammation (IL6, CXCL8, CXCL9, CXCL10), the immune response (IFNG and CD274, encoding the immune checkpoint regulators PD-L1) and likely the tumour immune infiltrate itself.