XDH and neoplasm: We found significantly higher immune scores in tumours with high expression of XDH: median of 95.9 for tumours with low XDH compared with median of 230.6 for tumours with high XDH (P=1.6 × 10−6) indicating that higher tumour uricogenesis is associated with higher expression of various immune and pro-inflammatory cytokines and denser tumour immune infiltration.