C-X-C motif chemokine receptor 4 (CXCR4), which plays an important role in the cell proliferation and metastasis of lung adenocarcinoma, has also been demonstrated to be a transcriptional target of AIB1 involved in promoting cell proliferation in breast and bladder cancers [19, 20]. This evidence concerns the gene CXCR4 and lung adenocarcinoma.