Of the five lung adenocarcinoma cell lines analyzed, H1975, H1993, H2073, and PC9 cells showed relatively high levels of endogenous AIB1 protein expression, whereas A549 cells showed relatively low levels of AIB1 protein expression (Fig. 2a left).Two lung adenocarcinoma cell lines, H1975 and H1993, were then treated with two specific shRNAs against AIB1, and the shRNAs could efficiently knock down endogenous AIB1 in lung adenocarcinoma cells (Fig. 2a right). Here, NCOA3 is linked to lung adenocarcinoma.