To identify potential downstream targets regulated by AIB1 that were involved in lung adenocarcinoma cell invasion and/or metastasis, the mRNA expression profiles of shAIB1-transfected H1993 cells were compared with those of the control H1993 cells using a Human Tumor Metastasis RT2 Profiler TM PCR Array containing 84 cell metastasis-related genes. The gene discussed is NCOA3; the disease is neoplasm.