ACTH-independent CS was determined by an ACTH level of 3.21 pg/mL (Table 1), and computed tomography of her upper abdomen showed a lipid-poor left adrenal adenoma (size, 2.8 cm) and a lipid-poor right adrenal adenoma (size, 1.1 cm; Fig. 1). Here, POMC is linked to adrenal cortex adenoma.