As shown in Table 2, MKRN2 protein levels were negatively correlated with clinicopathological parameters, including differentiation (P < 0.001), lymph node metastasis (P = 0.002), and pathological TNM stage (P = 0.005), whereas correlations between MKRN2 protein levels and tumor size (P = 0.936), histological type (P = 0.562), and patient age (P = 0.374) and sex (P = 0.318) were not statistically significant. This evidence concerns the gene MKRN2 and metastatic malignant neoplasm in the lymph nodes.