MKRN2 and non-small cell lung carcinoma: As shown in Table 3,immunohistochemistry of 34 pairs NSCLC tissues revealed that levels of p-Akt (Ser473) were low in cells exhibiting high levels of MKRN2 expression, whereas p-Akt (Ser473) levels were high in cells exhibiting low levels of MKRN2 expression (Fig. 4d), indicating a negatively correlated relationship between MKRN2 expression and p-Akt (P = 0.03).