EGFR and non-small cell lung carcinoma: Though epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have significantly improved outcome of EGFR mutation positive advanced non-small cell lung cancer (NSCLC), most of these patients develop resistance to first generation EGFR TKIs after a median of 10–12 months, in which about 50–60% of these tumors harbor EGFR T790M resistance mutation [3–5].