Several other candidates have potential matches to pathways that may be implicated in endothelial processes linked to malaria pathology such as Peroxiredoxin-2 (anti-oxidant), Syntaxin-3 (vesicle formation), Rab GTPase-activating protein (regulation of exocytosis), Trypsin-3 (clotting cascade), Calreticulin (stimulates NO production) and ADAM19 (cell adhesion and signal transduction). The gene discussed is PRSS3; the disease is malaria.