Based on our data, a novel type of CAR-T cells, dCAR-T cells, can exert significant cytotoxicity only in the presence of cognate tumor cells (AsPC-1) expressing both CEA and MSLN, which is comparable with that obtained with conventional CAR-T cells and alleviates “on-target, off-tumor” toxicity. This evidence concerns the gene CEACAM5 and neoplasm.