After an overnight incubation, significant cell-mediated cytotoxicity was observed in dCAR-T cells co-cultured with cognate tumor cells expressing both CEA and MSLN, with approximately 80% of target cell apoptosis which was similar to that of conventional CAR-T cells (CEA-CAR T or MSLN-CAR T) (Fig. 2g). Here, CEACAM5 is linked to neoplasm.