MAP2K7 and colorectal carcinoma: Then, the interaction of BKM120 (PI3K inhibitor), MEK162 (MEK inhibitor) and SN38 was evaluated using a full-range dose matrix approach and SRB cytotoxicity tests for two-drug combinations (BKM120-MEK162, MEK162-SN38, and BKM120-SN38) in seven molecularly characterized CRC cell lines (Table 1).