As illustrated in Fig. 3a, 69 significantly enriched GO terms (P < 0.05) were identified, such as negative regulation of cell growth (GO: 0030308), growth factor activity (GO: 0008083), positive regulations of ERK1 and ERK2 cascade (GO: 0070374), and sodium channel complex (GO: 0034706), etc. ERK1 and ERK2 had been suggested to play an important role in regulating cell invasion, cell proliferation, and colony formation in triple-negative breast cancer cell lines [39]. The gene discussed is MAPK1; the disease is triple-negative breast carcinoma.