TLR7 and peeling skin syndrome: Karlsen et al. subsequently reported [108] the response of B cells to stimulation with TLR7 and TLR9; a low frequency of IL-10-positive pre-switched memory B cells was observed regardless of the presence of stimulation with TLR7 and TLR9, suggesting that the B-cell population and responsiveness in pSS patients differ from those in healthy subjects.