Interestingly, the immunization of M3R mimotope (which has structure similar to that of the original epitope) effectively inhibited the sialadenitis, the production of pro-inflammatory cytokines, and the autoantibody against M3R and apoptotic pathway mediated by Fas, suggesting a crucial role of EGF signaling in inflammation and apoptosis in SS. This evidence concerns the gene EGF and synovial sarcoma.