CASP3 and synovial sarcoma: In addition, an up-regulation of 120-kD α-fodrin [44,45,46,47] (which is known as an SS-related autoantigen) was detected in HSY cells that were transfected with full-length caspase 3 and μ-calpain cDNA, suggesting that α-fodrin plays a crucial role in Fas-mediated apoptosis in SS.