The CSPG4 antigen (the melanoma-associated chondroitin sulfate proteoglycan, MCSP, or the high molecular weight melanoma-associated antigen, HMW-MAA) is expressed in 90% of melanoma lesions [26] and other malignancies (e.g., sarcomas and gliomas [27,28]). This evidence concerns the gene CSPG4 and central nervous system cancer.