While there are divergent views on the actual role of SOD2 in cancer, there is growing evidence that the loss of SOD2 function may not facilitate metastatic disease progression as previously thought; rather, there is an indication from experimental and epidemiological studies that enhanced SOD2 expression levels correlate with metastatic malignantization and disease progression in various cancer types [13]. The gene discussed is SOD2; the disease is metastatic neoplasm.