These findings are consistent with the demonstrated suppression of the invasion and migration of hepatocellular carcinoma (HCC) cells by hsa-miR-324-5p-induced down-regulation of the specificity protein 1 (SP1) and E26 transformation-specific protein 1 (ETS1) [25], where decreased SP1 binding to the SOD2 promoter inhibits the constitutive activation of SOD2 in breast cancer cells [13], since the proximal promoter that mediates the transcription of SOD2 is TATA-less and contains binding sites for several transcription factors, including ETS1 and SP1. This evidence concerns the gene SP1 and hepatocellular carcinoma.