SOD2 and neoplasm: The SOD2 expression data for CRC was corroborated by that which was obtained from the analysis of the TCGA CRC dataset (n = 237) using the Oncomine platform (https://www.oncomine.org), with a 8.47-fold (n = 22, p = 5.55 × 10−10), 1.93-fold (n = 101, p = 1.92 × 10−13), 1.88-fold (n = 60, p = 2.88 × 10−10), and 1.45-fold (n = 6, p = 6.25 × 10−4) upregulation of SOD2 expression level was observed in the colon mucinous adenocarcinoma, colon adenocarcinoma, rectal adenocarcinoma, and rectal mucinous adenocarcinoma compared to the non-tumor ‘normal’ colorectal tissues (Figure 1B).