There is documented correlation or association between down-regulated miRNA expression, and tumor initiation or metastatic disease progression [17,18], however, there is a dearth of information regarding SOD2-regulated miRNA(s) in CRC, and regarding how the epigenetic modulation of SOD2 contributes to the CSC-like and metastatic phenotype of CRC cells. Here, SOD2 is linked to metastatic neoplasm.