SOD2 and colorectal carcinoma: To better understand the relationship between SOD2 and hsa-miR-324-5p, as well as to rule out any modulatory loop between them in CRC cells, we employed a bioinformatics approach to generate the crystal structure of SOD2 based on PDB:2ADQ from the Protein Data Bank (www.rcsb.org/pdb/gene/SOD2; Figure 2A).