Furthermore, we investigated the pharmacological targetability of the SOD2-enriched CRC cells, by evaluating the effect of 4-AAQB (Figure 4A) on the viability and proliferation of the CRC wild type or sorted side-population (SP) cells, against the background of 4-AAQB bioinformatics-based predicted health benefits in several human systems, with highest (~99%) health effects in the gastrointestinal system, which includes the colon and rectum (Supplementary Figure S1). This evidence concerns the gene SOD2 and colorectal carcinoma.