SOD2 and neoplasm: Interestingly, corroborating the critical role of epigenetic alterations in the unrestrained growth, invasion, colonization and acquired resistance of cancerous cells [16,17,18,30,31], we validated the reciprocal suppression of the pro-tumorigenic and pro-metastatic SOD2 and suppressor miR, hsa-miR-324 ex-vivo, showing that the expression of hsa-miR-324 levels in the resected tumor tissue from 4-AAQB- and/or FOLFOX- treated mice was significantly up-regulated, while conversely, that of SOD2 was reduced markedly, compared to the untreated group (Figure 8).