Having established a positive correlation between SOD2 expression, disease progression, and metastasis (Figure 3A,B), as well as corroborating the inverse correlation between SOD2 and hsa-miR-324 expression in CRC by using the TCGA colon cancer (COAD) dataset (n = 234, σ= 0.695, p = 0.048) (Figure 3C), we then evaluated the prognostic potential of SOD2 (n = 315) and hsa-miR-324-5p (n = 250) in CRC patients based on the TCGA COAD cohort using the Kaplan-Meier (KM) survival plot. The gene discussed is SOD2; the disease is malignant colon neoplasm.