CCNA2 and glioblastoma: Preclinical studies on the effect of combination of MAG and honokiol in U87MG and LN229 glioma cells and the human GBM orthotopic xenograft model showed that MAG acts synergistically with honokiol and halts tumor progression by regulating cyclin-A, -D1 and CDK-2, -4, -6 and through induction of autophagy and apoptosis [136].