BMI1 and neoplasm: Tumor cells associated to the vascularized region of glyomas harbor an activated EZH2, while GSCs developing into the hypoxic part of the tumor express BMI1 (a component of the Polycomb Repressor Complex1), dual pharmacologic inhibition of EZH2 and BMI1 in cell culture and a preclinical model was more effective than the use of a single pharmacological agent [56].