KMT2A and leukemia: The EPZs class of compounds, including EPZ004777 and its derivative EPZ-5676, targeting DOT1L—a methyltransferase that regulates angiogenesis via VEGFR2 and is also involved in control of proliferation, differentiation and embryogenesis [68]—have been positively validated in a cellular model for selective killing of MLL-rearranged leukemia cells in culture, while having a significantly less toxic effect on non MLL-rearranged cells [132].