HRAS and neoplasm: It was also shown that SAM effectively induces DNA methylation on oncogenes involved in cancerogenesis, such as S-myc and H-Ras, leading to their inactivation and also stimulates silencing of expression of critical tumor growth-/tumor angiogenesis- promoting genes (MMP2, MMP9, VEGF, PAI-1, TGF-β, RUNX2) [122,124].