Research performed on tumor-conditioned HUVECs, revealed the angiostatic potential of zebularine via induction of ICAM1 expression and restoration of leukocyte adhesion to endothelial cells [85], as well as restoration of the expression of the anti-angiogenic genes TSP1, JUNB, and IGFBP5 [33]. The gene discussed is THBS1; the disease is neoplasm.