Conversely, siRNA-mediated targeting of murine EZH2, acting on the tumor vasculature but not the tumor cells, had a stronger inhibitory effect on tumor growth, and the simultaneous addition of murine and human siRNA lead to a maximal inhibitory affect, supporting the notion that EZH2 targeting can be a therapeutic approach acting on both the tumor cells and the vasculature [5]. This evidence concerns the gene EZH2 and neoplasm.