CDKN2A and neoplasm: Both 5-azacytidine and decitabine can reactivate epigenetically silenced tumor suppressor genes, including cell-cycle inhibitors (p14ARF, p15INK4b, p16INK4a, p21Cip/WAF, p27Kip1), pro-apoptotic genes (ARHI, APC, RASSF1A, HIC1), DNA repair genes (BRCA1, GSTP1, hMLH1, MGMT), genes related to metastasis (CDH1, DAPK, maspin, TIMP-3, TSP1, VHL) or differentiation markers (e.g., RARβ2) that are silenced by methylation of CpG islands on their promoters, thus decreasing tumor growth [78].