Antiangiogenic potential was also observed in testing the decitabine antimetabolite guadecitabine, that was shown to reactivate a few epigenetically silenced tumor suppressor genes: CDKN2A, DLEC1, RUNX3 and reduce tumor growth via inhibition of angiogenesis in a hepatocellular carcinoma model [83,84]. The gene discussed is CDKN2A; the disease is neoplasm.