Overexpression or enhanced activity of PRMTs has been recognized in multiple type of cancers (breast, prostate, lung, colon, leukemias), cardiovascular diseases, but also in neurodegenerative diseases (Huntington’s disease (PRMT5) and Alzheimer disease (PRMT5)) [129,142,143,144,145]. This evidence concerns the gene PRMT5 and early-onset autosomal dominant Alzheimer disease.