The inhibition of G9a via BIX-01294 was also shown to impair the stability of hypoxia-inducible factor-1α (HIF-1α, one of the key regulators of tumor growth and angiogenesis) by decreasing gene expression of proline hydroxylase 2 (PHD2) and the half-life of HIF-1α in HepG2 human hepatocellular carcinoma cells [66]. This evidence concerns the gene HIF1A and hepatocellular carcinoma.