VEGFA and neoplasm: Curcumin displays multiple antiangiogenic properties, including dowregulation of the transcription factors NF-κB and STAT3; proangiogenic factors VEGF, bFGF, COX-2; inhibition of endothelial cell migration and invasion [93,108,109] as well as antiproliferative and pro-apototic effects on tumor cells [110,111].