PLAU and cancer: Also, other genes identified as crucial for cancer progression, including E-cadherin (CDH1), von-Hippel-Lindau (VHL), protein kinase D1 (PKD1), maspin, cysteine-rich protein with Kazal motif (RECK) or urokinase-type plasminogen activator (uPA) were found to be regulated via DNA methylation [35,36,37].