Additionally, TAMs play a critical role in the tumor microenvironment by secreting second messengers such as IL-8 or IL-6 via NF-κB activation, thus promoting the tumor microenvironment and regulating angiogenesis, which, in turn, correlates with poor outcome and malignant features in breast cancer [35,36,46,47]. This evidence concerns the gene CXCL8 and breast carcinoma.