Additionally, TAMs play a critical role in the tumor microenvironment by secreting second messengers such as IL-8 or IL-6 via NF-κB activation, thus promoting the tumor microenvironment and regulating angiogenesis, which, in turn, correlates with poor outcome and malignant features in breast cancer [35,36,46,47]. The gene discussed is NFKB1; the disease is neoplasm.