Field studies have similarly found that among those with high perceived control there is an attenuation of the associations of major stressful life events with negative affect and depressive symptoms e.g., King et al. (2015) and Mausbach (2007); of the association of lifetime trauma and the inflammatory marker, CRP (Elliot et al., 2017); and the associations between major depression and poorer natural killer cell activity (NKCA) (Reynaert, 1995). This evidence concerns the gene CRP and major depressive disorder.