TFRC and cancer: After the demonstration that HFt-LBT Tb(III) maintained the overall structure of the wild type mouse HFt, binding and internalization of the construct was analyzed in selected cancer cell lines: in fact, it is known that HFt is recognized and internalized by CD71 receptor (also known as TfR1), which is overexpressed in many types of tumor cells but not in normal cells and healthy tissues [53].