In renal cell carcinoma cell lines miR-145-5p is dysregulated and several targets, including e2F-associated phosphoprotein (EAPP), Heparan Sulfate 6-O-Sulfotransferase 2 (HS6ST2), Lysyl Oxidase (LOX), Transforming Growth Factor beta-2 (TGFB2) and Vaccinia-related Kinase 2 (VRK2), were confirmed [37]. This evidence concerns the gene VRK2 and hereditary clear cell renal cell carcinoma.