EFEMP1 and autosomal recessive polycystic kidney disease: To investigate the expression and localization of EFEMP1 protein in human liver, we performed immunohistochemistry (IHC) on normal control and BA livers, and we also included disease control livers from patients with total parenteral nutrition-associated (TPN) cholestasis and autosomal recessive polycystic kidney disease (ARPKD).