TRAF6 and cardiac hypertrophy: The administration of apocynin (APO), a NADPH oxidase inhibitor or ROS scavenger N‐acetyl‐cysteine (NAC), can block these responses in the hypertrophic heart.43, 60 Similarly, another research group found that ROS‐mediated activation of TRAF6 promotes cardiac remodelling and the blockage of ROS production, using NAC or APO, dramatically reduces the cardiac hypertrophy and dysfunction caused by TRAF6 overexpression through attenuation of phosphorylation of TAK1.