The overexpression of TRAF6 aggravates Ang II‐ or pressure overload‐induced cardiac hypertrophy in animal models.43, 60 More importantly, the expression and activity of TRAF6 are increased by oxidative stress.61, 62 The activity of NADPH oxidase and reactive oxygen species (ROS) levels is dramatically increased in experimental model of cardiac pressure overload‐induced heart dysfunction and their increase is accompanied by TRAF6. This evidence concerns the gene TRAF6 and cardiac hypertrophy.