For instance, Ub‐specific protease‐14 (USP14) negatively regulates the activity of proteasomes by removing Lys48‐linked Ub chains, whereas cylindromatosis tumour suppressor (CYLD) only acts on lysine 63 linkage‐specific Ub polymers.29 For example, CYLD attenuates TAK1 signalling by removing K63‐linked polyubiquitin chain of TAK1. Here, CYLD is linked to neoplasm.