To evaluate the performance of hypermethylation analysis of ASCL1,LHX8 and ST6GALNAC5 in physician‐taken cervical scrapes for detection of cervical cancer and cervical intraepithelial neoplasia (CIN) grade 3 in women living with HIV (WLHIV) in South Africa. The gene discussed is LHX8; the disease is cervical carcinoma.