As the major effector cytokine in EoE [23, 24], IL-13 stimulates epithelial production of eotaxin-3 (aka CCL26), a potent chemoattractant for eosinophils and basophils [25–27], and promote tissue eosinophilia [28, 29]. The gene discussed is CCL26; the disease is eosinophilic esophagitis.