Other TGFβ target genes essential in fibrosis and extracellular matrix remodeling, yet to be studied in the context of EoE, include connective tissue growth factor (CTGF) [46], insulin-like growth factor binding protein (IGFBP)-3 [47] and lysyl oxidase (LOX) [48]. The gene discussed is LOX; the disease is eosinophilic esophagitis.