YAP1 and cancer: Thus, in a wide range of cancers, YAP might be regulated by the crosstalk between CAFs, ECM and cancer cells, as described in “YAP regulated mechanical properties of tissues”; YAP activity in CAFs might induce ECM remodeling that in turn would induce YAP nuclear translocation and phosphorylation by Src family kinases in cancer cells (Fig. 6).