CLOCK and atherosclerosis: These signals may impair function of the clock in ECsto impair other EC’s or to impair SMCs, though it is still not clear if ECclocks communicate with SMC clocks and if there is even EC to EC cell communication.Understanding oscillations of the clock in the cellular milieu of the vasculaturewill be crucial in delineating how clocks can influence pathology of hypertensionand atherosclerosis and ultimately permit the development of improved therapeuticapproaches that include timing and clocks into maximizing efficacy andtreatment.