CD68 and mucopolysaccharidosis type 3B: A neuroimmune response is a common feature of MPS IIIB,29, 30, 31 and Naglu−/− mice show pronounced microglial activation.11, 30, 31 To assess whether N-iNSCs had any effect upon microglial activation, we stained sections of unaffected control (Naglu+/−), vehicle-injected Naglu−/− (−/− vehicle), and iNSC-grafted Naglu−/− (−/− treated) brains for the microglial marker CD68.