NLRP3 and myelodysplastic syndrome: This short note combines, (A) the 2015 and 2016 observations of Basiorka et al. (14, 15) and 2016 work of Sallman (16)—all three reporting that NLRP3 inflammasome constitutes a final common effector node driving a core element of the pathophysiology of MDS with, (B) the 2017 data sets of Ahn et al. (26) and of Lin et al. (27) plus the 2018 report of Hao et al. (28)—all three reporting that the NLRP3 inflammasome can be inhibited by the century old drug MB.