Differentiating therapies for (a) low risk MDS with repeated erythropoietin, lenalidomide, or various drugs to diminish immune mediated or inflammation related hematopoietic cell apoptosis, and (b) drugs for high risk MDS like azacitidine, decitabine, dose cytarabine, or marrow cytotoxic chemotherapy (7, 9, 10) leave room for improvement since across all MDS subtypes overall mortality at 5 years remains around 50% (1). This evidence concerns the gene EPO and myelodysplastic syndrome.