TYMS and chronic myelogenous leukemia, BCR-ABL1 positive: At the exon level, high splicing index affected the dysregulation of normal cellular processes in drug-treated CML cases, including up-regulation of Myeloperoxidase (MPO)-induced neutrophil degranulation affecting the innate immune system [24], TPX2 up-regulation, suggesting inhibition of TP53 transcriptional activity [25, 26], and TYMS, suggesting CML cells are more within the G1/S transition through more formation of TMP and dihydrofolate.