The genes were up-regulated in the AGPAT5-mediated triacylglyceride (significance=2.27, p=0.005357), glycerophospholipid synthesis (significance=1.51, p=0.0031133), NOP58-mediated SUMOylation of RNA binding proteins (significance=1.89, p=0.012906), SNRPD1-mediated metabolism of non-coding RNA (significance=1.84, p=0.014454), mRNA processing (significance=1.55, p=0.028078), HLTF-mediated Retinoblastoma (RB) in cancer (significance=1.7, p= 0.019966), and E3 ubiquitin ligases ubiquitinate target proteins pathways (significance=1.63, p=0.023481). The gene discussed is HLTF; the disease is retinoblastoma.