Further, significant up-regulation of LAPTM4B, HLTF, PIEZO2, CFH, CD109, ANGPT1 influence autophagy, stem cell, complement system, TGFβ Receptor and homeostasis pathway subsequently leading to resistance in >1% BCR-ABL copies of CML treated cases. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.