The highly significant down-regulation of STAT6, FOS, TGFBR2, and ITK and up-regulation of MPO, TPX2, and TYMS in drug-treated CML cases relative to normal samples led to the up-regulation of cell cycle, DNA replication, and DNA repair pathways and down-regulation of immune system, chemokine and interleukin signaling, TCR signaling, TGF beta signaling, and MAPK signaling pathways. Here, ITK is linked to chronic myelogenous leukemia, BCR-ABL1 positive.