Further, down-regulation of SKAP1 (Src Kinase Associated Phosphoprotein 1), ITK and TGFBR2 and FOS in CML cases led to down-regulation of the TCR signaling and immune system pathways Additionally, the Src-family kinases (SFKs) have been implicated in BCR-ABL signaling and in the progression of CML [27]. This evidence concerns the gene FOS and chronic myelogenous leukemia, BCR-ABL1 positive.