CLU and posterior cortical atrophy: In the present study, we confirmed that the DTX-resistant PC3-DR and DU145-DR cell lines used in the RNA-seq analysis and other experiments displayed significant upregulation of proteins previously implicated by our group and others in PCa progression and DTX resistance [8, 9, 19–23] including LEDGF/p75, CLU, and ATP-binding cassette sub-family B member 1 (ABCB1), compared to the sensitive cells (Figure 1A-1C).