EGFR and metastatic colorectal cancer: Skin toxicities (ST) like papulopustular rash (acneiform eruption), erythema, skin fissures, hair and nail changes, paronychia, and xerosis are frequent adverse effects (AE) when targeting the EGFR in solid cancers like metastatic colorectal cancer (mCRC), lung cancer, head and neck cancers and others [1].