To further investigate the clinical significance of Lamp2 expression in the development and progression of HCC, the tissue microarray cohort (286 patients) was divided into 2 groups based on the overall expression level of Lamp2: a high Lamp2 expression group (n = 143) and a low Lamp2 expression group (n = 143).We found strong negative correlations between Lamp2 expression and many progressive clinical features, including the AFP serum level (> 20 ng/Ml, P = 0.024), capsular formation (absent, P = 0.024), and microvascular invasion (present, P < 0.001) (Table 1). The gene discussed is AFP; the disease is hepatocellular carcinoma.