Treatment with GYS1 shRNA resulted in decreases in the expression of IL-1β, IL-6, and CCL-2 but not IL-8 and IFN-γ in TNF-α-induced RA FLSs compared with the scramble control (Figure 2A; Figure S2C in Supplementary Material). Here, CXCL8 is linked to rheumatoid arthritis.