CDK2 and colonic neoplasm: The previous research has shown that the substituent at the C-7 position of naringenin containing thiophenecarboxylate, phenyl carbonate, isobutyrate, methyl benzoate, and allyloxy inhibited effects on HCT116 human colon cancer cell line via block G1 cell cycle progression by interaction with cyclin-dependent kinase 2 (CDK2) (Yoon et al., 2013).