Based on the results of the PPI analysis by GeneMania and Cytohubba, 20 top-ranked proteins from 862 DEGs are thought to participate in the core pathway of HCC, such as TOP2, GINS1, EZH2, TTK2, CDK1, BUB1B, TPX2, CENPF, and MAD2L1. This evidence concerns the gene CENPF and hepatocellular carcinoma.