TOP2A and hepatocellular carcinoma: Based on the results of the PPI analysis by GeneMania and Cytohubba, 20 top-ranked proteins from 862 DEGs are thought to participate in the core pathway of HCC, such as TOP2, GINS1, EZH2, TTK2, CDK1, BUB1B, TPX2, CENPF, and MAD2L1.