Salmonella has been employed to deliver a variety of eukaryotic genes to tumours in vivo including apoptosis-associated genes Second mitochondrial derived activator of caspases (SMAC) and TNF-related apoptosis inducing ligand (TRAIL), as well as for cytokine gene therapy in subcutaneous tumour mouse models [11, 18, 37, 38]. Here, TNFSF10 is linked to neoplasm.