Considering that dysfunction of GATA-3 may correlate to distant metastases by reversing EMT, in combination with the observation that Notch3 positively regulates GATA-3 expression in vitro, we strongly proposed that Notch3 may be an essential factor in suppressing metastasis in breast cancer in some measure by inducing GATA-3 and inhibiting EMT. Here, GATA3 is linked to breast cancer.