KRT14 and epidermolysis bullosa simplex: To correct a dominantly inherited hotspot mutation (c.373C>T; p.R125H) in the keratin 14 gene (KRT14), which causes the generalized severe EBS subtype (EBS‐gen sev), we devised a 5′‐trans‐splicing strategy.21 In basal keratinocytes, which comprise the majority of cells within the basal epidermal layer, KRT14 encodes the intermediate filament protein keratin 14.