The aim of the study was to evaluate the effects of continuous hemofiltration on 28-day mortality and the levels of total bilirubin (TBIL), direct bilirubin (DBIL), total bile acids (TBA), lactate (Lac), ammonia, TNF-α and IL-6 in patients with bacterial sepsis complicated by liver dysfunction. The gene discussed is IL6; the disease is bacterial infectious disease with sepsis.