To explore the clinical relevance of FOXS1 on HH signaling‐dependent tumorigenesis, a large medulloblastoma cohort of 392 samples, which includes the four molecular subgroups (SHH signaling, n = 100; WNT signaling, n = 42; Group 3, n = 101; Group 4, n = 149) (Taylor et al., 2012), was examined (Downing et al., 2012). Here, SHH is linked to medulloblastoma.