NLRP3 and periodontitis: Periodontitis has been linked to increased expression of inflammasome‐sensing proteins NLRP3 and AIM2, mainly in the epithelial layer.22, 96 Moreover, a polymorphism in other NLR family member, NLRC5, has been linked to increased susceptibility to periodontitis,97 although how it contributes to this pathology has not been investigated.