These mutations lead to spontaneous inflammasome activation and paracrine IL‐1 signalling in keratinocytes from these patients.24 Polymorphisms of NLRP1 have also been associated with the autoimmune disease vitiligo, a condition characterized by the development of white patches in the skin due to lack of melanin.113 This is believed to occur through higher IL‐1β production and NLRP1 activation, although the specific mechanism by which the NLRP1 inflammasome shows greater functional activity is not known.114. This evidence concerns the gene IL1B and autoimmune disease.