NLRP3 and cryopyrin-associated periodic syndrome: Even before the discovery of the inflammasome, mutations in the NLRP3 gene were found to cause a spectrum of diseases known as cryopyrin‐associated periodic syndromes (or CAPS), which are associated with skin inflammation and rashes.111 Rashes typically disappear, or are controlled, after anti‐IL‐1β therapy, showing a role for IL‐1β signalling in skin rashes and in CAPS in general.112