Interestingly, epithelial IL‐18 signalling during colitis targets epithelial cells themselves as Il‐18R−/− in haematopoietic cells fails to rescue mice from colitis, whereas specific Il‐18R−/− in epithelial cells protects mice from DSS‐induced colitis.73 Recent studies also point to a role of AIM2 in DSS‐induced colitis. This evidence concerns the gene IL18 and colitis.