In fact, recent studies suggest that NLRP3 is not expressed by epithelial cells in the colon of mice, placing tissue‐resident macrophages as the principal contributors to this NLRP3‐dependent response.71 These studies suggest that although NLRP3 is a main actor in IBD, the epithelial cell layer's contribution to IBD might be NLRP3 independent. This evidence concerns the gene NLRP3 and inflammatory bowel disease.