IBD is a chronic inflammation of the digestive system associated with the alterations of the gut microbiota.65 The most common mouse model of IBD is to induce colitis using dextran sodium sulphate (DSS), which damages the epithelium, increasing gut permeability.66 Inflammasome responses in experimental models of colitis are well characterized, but mainly in monocytes and macrophages.67 In such models, NLRP3 inhibition ameliorates DSS‐induced colitis.68, 69, 70 However, these studies fail to show a specific role for epithelial cells, despite these being the main cell type affected by IBD. Here, NLRP3 is linked to colitis.