One study reported on decreased atherosclerotic lesion size in ApoE3-Leiden mice with transgenic overexpression of ANGPTL 430,54, while Aryal et al. showed decreased atherosclerosis in LDLR null mice with global knock out of ANGPTL4 and accelerated atherosclerosis in LDLR null mice lacking ANGPTL4 only in the hematopoietic cells55. Here, LDLR is linked to atherosclerosis.