Using the SEPSIS-3 criteria, the PCT/HLA-DRA ratio also yielded better results than PCT to differentiate sepsis (n = 87 patients) from non sepsis patients (n = 53 patients): PCT [0.82 (0.75–0.90), 0.038]; PCT/HLA-DRA ratio [0.87 (0.81–0.93), 0.031] [AUROC (CI95%), p] (p = 0.004 in the Delong Test). This evidence concerns the gene CALCA and Sepsis.