Given the essentiality of the three components in nucleosome remodeling and the transcription regulation functions of the SWI/SNF complex, it is apparent that the entire SWI/SNF complex has a synthetic lethality interaction with AURKA in tumor cells in which mutations in the key components of the SWI/SNF complex causes the induced essentiality or the oncogene addiction of AURKA for cell survival. The gene discussed is SMARCA1; the disease is neoplasm.